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Effect of asthma severity on symptom perception in childhood asthma BJMBR
Cabral,A.L.B.; Conceição,G.M.; Saldiva,P.H.N.; Martins,M.A..
Individual ability to perceive airway obstruction varies substantially. The factors influencing the perception of asthma are probably numerous and not well established in children. The present study was designed to examine the influence of asthma severity, use of preventive medication, age and gender on the association between respiratory symptoms (RS) and peak expiratory flow (PEF) rates in asthmatic children. We followed 92 asthmatic children, aged 6 to 16 years, for five months. Symptom scores were recorded daily and PEF was measured twice a day. The correlations among variables at the within-person level over time were analyzed for each child and for the pooled data by multivariate analysis. After pooling the data, there was a significant (P<0.05)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Asthma severity; Pulmonary function tests; Symptom perception; Childhood asthma.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300006
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Insights into the physiological function of cellular prion protein BJMBR
Martins,V.R.; Mercadante,A.F.; Cabral,A.L.B.; Freitas,A.R.O.; Castro,R.M.R.P.S..
Prions have been extensively studied since they represent a new class of infectious agents in which a protein, PrPsc (prion scrapie), appears to be the sole component of the infectious particle. They are responsible for transmissible spongiform encephalopathies, which affect both humans and animals. The mechanism of disease propagation is well understood and involves the interaction of PrPsc with its cellular isoform (PrPc) and subsequently abnormal structural conversion of the latter. PrPc is a glycoprotein anchored on the cell surface by a glycosylphosphatidylinositol moiety and expressed in most cell types but mainly in neurons. Prion diseases have been associated with the accumulation of the abnormally folded protein and its neurotoxic effects;...
Tipo: Info:eu-repo/semantics/article Palavras-chave: PrPc; Cellular function; Transmissible spongiform encephalopathies; Laminin; Signal transduction; Copper.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500005
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